Pregnancy complications following fertility treatment-disentangling the role of multiple gestation.

ABSTRACT: Background:To assess the extent to which multiple gestations mediate risk of pregnancy complications from fertility treatment and to address possible confounding by the underlying infertility. Methods:From the nearly 1.8 million pregnancies recorded in the Swedish Medical Birth Register between 1996 and 2013, we selected the 9.9% (N = 174 067) that occurred to couples with known trouble conceiving (clinical infertility). Fertility treatment was identified from self-reports, medical records and procedural information from fertility clinics. We used logistic regression to estimate odds ratios (ORs) and their 95% confidence intervals (CIs), and decomposed the total effect into direct and mediated effects to estimate the proportion mediated by multiple gestations. Results:Compared with pregnan

SUBMITTER: Oberg AS 

PROVIDER: S-EPMC6124622 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature