MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.

ABSTRACT: The versatility and universality of Ca²⁺ as intracellular messenger is guaranteed by the compartmentalization of changes in [Ca²⁺]. In this context, mitochondrial Ca²⁺ plays a central role, by regulating both specific organelle functions and global cellular events. This versatility is also guaranteed by a cell type-specific Ca²⁺ signaling toolkit controlling specific cellular functions. Accordingly, mitochondrial Ca²⁺ uptake is mediated by a multimolecular structure, the MCU complex, which differs among various tissues. Its activity is indeed controlled by different components that cooperate to modulate specific channeling properties. We here investigate the role of MICU3, an EF-hand containing protein expressed at high levels, especia

SUBMITTER: Patron M 

PROVIDER: S-EPMC6124646 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature