Exploring immuno-regulatory mechanisms in the tumor microenvironment: Model and design of protocols for cancer remission.

ABSTRACT: The tumor microenvironment comprising of the immune cells and cytokines acts as the 'soil' that nourishes a developing tumor. Lack of a comprehensive study of the interactions of this tumor microenvironment with the heterogeneous sub-population of tumor cells that arise from the differentiation of Cancer Stem Cells (CSC), i.e. the 'seed', has limited our understanding of the development of drug resistance and treatment failures in Cancer. Based on this seed and soil hypothesis, for the very first time, we have captured the concept of CSC differentiation and tumor-immune interaction into a generic model that has been validated with known experimental data. Using this model we report that as the CSC differentiation shifts from symmetric to asymmetric pattern, resistant cancer cells start acc

SUBMITTER: Ganguli P 

PROVIDER: S-EPMC6124765 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature