Transcriptome analysis of immune genes in peripheral blood mononuclear cells of young foals and adult horses.

ABSTRACT: During the neonatal period, the ability to generate immune effector and memory responses to vaccines or pathogens is often questioned. This study was undertaken to obtain a global view of the natural differences in the expression of immune genes early in life. Our hypothesis was that transcriptome analyses of peripheral blood mononuclear cells (PBMCs) of foals (on day 1 and day 42 after birth) and adult horses would show differential gene expression profiles that characterize natural immune processes. Gene ontology enrichment analysis provided assessment of biological processes affected by age, and a list of 897 genes with ≥2 fold higher (p<0.01) expression in day 42 when compared to day 1 foal samples. Up-regulated genes included B cell and T cell receptor diversity genes; DNA replication

SUBMITTER: Tallmadge RL 

PROVIDER: S-EPMC6124769 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature