Dynamic image denoising for voxel-wise quantification with Statistical Parametric Mapping in molecular neuroimaging.

ABSTRACT:

Purpose

PET and SPECT voxel kinetics are highly noised. To our knowledge, no study has determined the effect of denoising on the ability to detect differences in binding at the voxel level using Statistical Parametric Mapping (SPM).

Methods

In the present study, groups of subject-images with a 10%- and 20%- difference in binding of [123I]iomazenil (IMZ) were simulated. They were denoised with Factor Analysis (FA). Parametric images of binding potential (BPND) were produced with the simplified reference tissue model (SRTM) and the Logan non-invasive graphical analysis (LNIGA) and analyzed using SPM to detect group differences. FA was also applied to [123I]IMZ and [11C]flumazenil (FMZ) clinical images (n = 4) and the variance of BPND was evaluated.

Results

Estimations f

SUBMITTER: Tsartsalis S 

PROVIDER: S-EPMC6124809 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature