Brain Functional Magnetic Resonance Imaging Cue-reactivity Can Predict Baclofen Response in Alcohol Use Disorders.

ABSTRACT:

Objective

Baclofen is a promising treatment for alcohol use disorders (AUD), although its clinical response in humans is mixed. The present study aimed at investigating the impact of baclofen treatment on cue-induced brain activation pattern and its relationship with relapse outcomes.

Methods

Twenty-three inpatients with AUD underwent a functional magnetic resonance imaging cue-reactivity task before beginning medication with baclofen and 2 weeks later. Twelve additional inpatients with AUD, who did not receive any anticraving medications, formed the control group. All subjects were prospectively followed up for 90 days post-discharge or until lapse to first alcohol use.

Results

Whole-brain linear mixed effects analysis revealed a significant group-by-time interaction

SUBMITTER: Holla B 

PROVIDER: S-EPMC6124881 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature