Prevention of Diabetes: Countless Opportunities and Clear Challenges.

ABSTRACT: Prevention of diabetes poses significant challenges; especially when applied as public health intervention. While several trials, most importantly Diabetes Prevention Program, show that intensive lifestyle modification leading to weight loss is the most important intervention, many individuals and some populations may show resistance to these interventions. Roadblocks to lifestyle intervention alone or in combination include: age, some ethnic groups (e.g., south Asians), genetic make-up, and some characteristics of body phenotype. Recent data show that non-alcoholic fatty liver disease along with insulin resistance may constitute 'metabolically unhealthy phenotype'. These subgroups would need more intensive interventions to convert prediabetes to normal glucose regulation. Whether 'fatty p

SUBMITTER: Misra A 

PROVIDER: S-EPMC6125020 | biostudies-literature | 2018 Jan-Feb

REPOSITORIES: biostudies-literature