Effects of sex on ethanol conditioned place preference, activity and variability in C57BL/6J and DBA/2J mice.

ABSTRACT: Previous studies of ethanol drinking in rodents have shown greater intake in females than in males, but the reasons behind this difference are unknown. To address one possible interpretation of the drinking difference, these studies tested the hypothesis that female and male mice differ in sensitivity to the rewarding effects of ethanol using the conditioned place preference (CPP) procedure. To increase the generalizability of the results, sex differences were examined in two inbred mouse strains known to differ in their sensitivity to ethanol reward: C57BL/6J (B6) and DBA/2J (D2). Mice were conditioned in an unbiased CPP procedure using either 1 or 2 g/kg ethanol. To detect possible differences in learning rate, they were tested once at the midpoint of conditioning and again after conditi

SUBMITTER: Cunningham CL 

PROVIDER: S-EPMC6125164 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature