The Phagocyte Oxidase Controls Tolerance to Mycobacterium tuberculosis Infection.

ABSTRACT: Protection from infectious disease relies on two distinct strategies: antimicrobial resistance directly inhibits pathogen growth, whereas infection tolerance protects from the negative impact of infection on host health. A single immune mediator can differentially contribute to these strategies in distinct contexts, confounding our understanding of protection to different pathogens. For example, the NADPH-dependent phagocyte oxidase (Phox) complex produces antimicrobial superoxide and protects from tuberculosis (TB) in humans. However, Phox-deficient mice display no sustained resistance defects to Mycobacterium tuberculosis, suggesting a more complicated role for NADPH Phox complex than strictly controlling bacterial growth. We examined the mechanisms by which Phox contributes to pr

SUBMITTER: Olive AJ 

PROVIDER: S-EPMC6125170 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature