CBLB Constrains Inactivated Vaccine-Induced CD8⁺ T Cell Responses and Immunity against Lethal Fungal Pneumonia.

ABSTRACT: Fungal infections in CD4⁺ T cell immunocompromised patients have risen sharply in recent years. Although vaccines offer a rational avenue to prevent infections, there are no licensed fungal vaccines available. Inactivated vaccines are safer but less efficacious and require adjuvants that may undesirably bias toward poor protective immune responses. We hypothesized that reducing the TCR signaling threshold could potentiate antifungal CD8⁺ T cell responses and immunity to inactivated vaccine in the absence of CD4⁺ T cells. In this study, we show that CBLB, a negative regulator of TCR signaling, suppresses CD8⁺ T cells in response to inactivated fungal vaccination in a mouse model of CD4⁺ T cell lymphopenia. Conversely, Cblb deficiency en

SUBMITTER: Nanjappa SG 

PROVIDER: S-EPMC6125178 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature