High-flow nasal oxygen versus noninvasive ventilation in adult patients with cystic fibrosis: a randomized crossover physiological study.

ABSTRACT:

Background

Noninvasive ventilation (NIV) is the first-line treatment of adult patients with exacerbations of cystic fibrosis (CF). High-flow nasal oxygen therapy (HFNT) might benefit patients with hypoxemia and can reduce physiological dead space. We hypothesized that HFNT and NIV would similarly reduce work of breathing and improving breathing pattern in CF patients. Our objective was to compare the effects of HFNT versus NIV in terms of work of breathing, assessed noninvasively by the thickening fraction of the diaphragm (TFdi, measured with ultrasound), breathing pattern, transcutaneous CO₂ (PtcCO₂), hemodynamics, dyspnea and comfort.

Methods

Adult CF patients who had been stabilized after requiring ventilatory support for a few days were enrolled an

SUBMITTER: Sklar MC 

PROVIDER: S-EPMC6125258 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature