Strongly Coupled Morphological Features of Aortic Aneurysms Drive Intraluminal Thrombus.

ABSTRACT: Over 75% of abdominal aortic aneurysms harbor an intraluminal thrombus, and increasing evidence suggests that biologically active thrombus contributes to the natural history of these potentially lethal lesions. Thrombus formation depends on the local hemodynamics, which in turn depends on morphological features of the aneurysm and near vasculature. We previously presented a hemodynamically motivated "thrombus formation potential" that predicts where and when thrombus might form. Herein, we combine detailed studies of the three-dimensional hemodynamics with methods of sparse grid collocation and interpolation via kriging to examine roles of five key morphological features of aneurysms on thrombus formation: lesion diameter, axial position, length, curvature, and renal artery position. Compu

SUBMITTER: Bhagavan D 

PROVIDER: S-EPMC6125404 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature