Structural Analysis of Redox-sensing Transcriptional Repressor Rex from Thermotoga maritima.

ABSTRACT: The cellular redox state of organisms continues to fluctuate during the metabolism. All organisms have various sensors that help detect and adapt to changes in the redox state. Nicotinamide adenine dinucleotides (NAD⁺/NADH), which are involved in various cellular metabolic activities as cofactors, have been revealed as the key molecules sensing the intra-cellular redox state. The Rex family members are well conserved transcriptional repressors that regulate the expression of respiratory genes by sensing the redox state according to the intra-cellular NAD⁺/NADH balance. Herein, we reported crystal structures of apo and NAD⁺- and NADH-bound forms of Rex from Thermotoga maritima to analyse the structural basis of transcriptional regulation depending on either

SUBMITTER: Park YW 

PROVIDER: S-EPMC6125430 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature