Changes in plasma membrane damage inducing cell death after treatment with near-infrared photoimmunotherapy.

ABSTRACT: Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer phototherapy modality using an antibody conjugated to a photosensitizer, IRDye700DX. When the conjugate binds to the plasma membrane and is exposed to NIR light, NIR-PIT-treated cells undergo swelling, and target-selective necrotic/immunogenic cell death is induced. However, the cytotoxic mechanism of NIR-PIT has not been elucidated. In order to understand the mechanism, it is important to elucidate how the damage to the plasma membrane induced by NIR light irradiation changes over time. Thus, in the present study, we investigated the changes in plasma membrane permeability using ions and molecules of various sizes. Na⁺ flowed into cells immediately after NIR light irradiation, even when the function of transporters or c

SUBMITTER: Nakajima K 

PROVIDER: S-EPMC6125438 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature