Unveiling epigenetic regulation in cancer, aging, and rejuvenation with in vivo reprogramming technology.

ABSTRACT: Reprogramming technology has enabled the fate conversion of terminally differentiated somatic cells into pluripotent stem cells or into another differentiated state. A dynamic reorganization of epigenetic regulation takes place during cellular reprogramming. Given that reprogramming does not require changes in the underlying genome, the technology can be used to actively modify epigenetic regulation. Although reprogramming has been investigated mostly at the cellular level in vitro, studies have reported that somatic cells are reprogrammable in multicellular organisms in vivo. In vivo reprogramming provides a potential strategy for regenerative medicine. Notably, recent studies using in vivo reprogramming technology to alter epigenetic regulation at organismal levels have revealed unapprec

SUBMITTER: Sogabe Y 

PROVIDER: S-EPMC6125454 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature