Colistin Heteroresistance and Involvement of the PmrAB Regulatory System in Acinetobacter baumannii.

ABSTRACT: Multidrug-resistant Acinetobacter baumannii infection has recently emerged as a worldwide clinical problem, and colistin is increasingly being used as a last-resort therapy. Despite its favorable bacterial killing, resistance and heteroresistance (HR) to colistin have been described. The purpose of the present study was to investigate the role of the PmrAB regulatory pathway in laboratory-selected mutants representative of global epidemic strains. From three unrelated A. baumannii clinical strains (sequence types 2, 3, and 20), eight colistin-resistant mutants were selected. Half of the mutants showed HR to colistin according to the reference method (population analysis profiling), whereas the other half exhibited stable resistance. M12I mutation within pmrA and M308R, S144KLAGS, and P170L

SUBMITTER: Charretier Y 

PROVIDER: S-EPMC6125516 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature