Population Pharmacokinetic Study of Amoxicillin-Treated Burn Patients Hospitalized at a Swiss Tertiary-Care Center.

ABSTRACT: The objective of this study was to investigate the population pharmacokinetics (PK) of amoxicillin in ICU burn patients and the optimal dosage regimens. This was a prospective study involving 21 consecutive burn patients receiving amoxicillin. PK data were analyzed using nonlinear mixed-effects modeling. Monte-Carlo simulations assessed the influence of various amoxicillin dosage regimens with identified covariates on the probability to achieve a target (PTA) value of time during which free amoxicillin concentrations in plasma exceeded the MIC (fT>MIC). A two-compartment model best described the data. Creatinine clearance (CL_CR) and body weight (BW) influenced amoxicillin CL and central volume of distribution (V₁), respectively. The median CL_CR

SUBMITTER: Fournier A 

PROVIDER: S-EPMC6125536 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature