Synergy between Circular Bacteriocin AS-48 and Ethambutol against Mycobacterium tuberculosis.

ABSTRACT: The increasing incidence of multidrug-resistant Mycobacterium tuberculosis strains and the very few drugs available for treatment are promoting the discovery and development of new molecules that could help in the control of this disease. Bacteriocin AS-48 is an antibacterial peptide produced by Enterococcus faecalis and is active against several Gram-positive bacteria. We have found that AS-48 was active against Mycobacterium tuberculosis, including H37Rv and other reference and clinical strains, and also against some nontuberculous clinical mycobacterial species. The combination of AS-48 with either lysozyme or ethambutol (commonly used in the treatment of drug-susceptible tuberculosis) increased the antituberculosis action of AS-48, showing a synergic interaction. U

SUBMITTER: Aguilar-Perez C 

PROVIDER: S-EPMC6125546 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature