CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production.

ABSTRACT: Foxp3⁺ regulatory T cells (Tregs) can inhibit immune responses and maintain immune tolerance by secreting immunosuppressive TGF-β1 and IL-10. However, the efficiency of Tregs become the major obstacle to their use for immunotherapy. In this study, we investigated the relevance of the C-type lectin receptor CD69 to the suppressive function. Compared to CD4⁺Foxp3⁺CD69^- Tregs (CD69^- Tregs), CD4⁺Foxp3⁺CD69⁺ Tregs (CD69⁺ Tregs) displayed stronger ability to maintain immune tolerance. CD69⁺ Tregs expressed higher levels of suppression-associated markers such as CTLA-4, ICOS, CD38 and GITR, and secreted higher levels of IL-10 but not TGF-β1. CD69⁺ Tregs from Il10^+/+

SUBMITTER: Yu L 

PROVIDER: S-EPMC6125584 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature