Linking sex differences to the evolution of infectious disease life-histories.

ABSTRACT: Sex differences in the prevalence, course and severity of infection are widespread, yet the evolutionary consequences of these differences remain unclear. Understanding how male-female differences affect the trajectory of infectious disease requires connecting the contrasting dynamics that pathogens might experience within each sex to the number of susceptible and infected individuals that are circulating in a population. In this study, we build on theory using genetic covariance functions to link the growth of a pathogen within a host to the evolution and spread of disease between individuals. Using the Daphnia-Pasteuria system as a test case, we show that on the basis of within-host dynamics alone, females seem to be more evolutionarily liable for the pathogen, with higher spore l

SUBMITTER: Hall MD 

PROVIDER: S-EPMC6125729 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature