CD4+ cell count recovery following initiation of HIV antiretroviral therapy in older childhood and adolescence.

ABSTRACT:

Objective

To investigate CD4 cell count recovery following ART initiation in perinatally HIV-infected children diagnosed in later childhood.

Design

Observational prospective cohort study of newly diagnosed children aged 6-15 in Harare, Zimbabwe.

Methods

Participants were enrolled into a cohort at seven primary healthcare clinics between January 2013 and January 2015. ART was initiated according to national guidelines and CD4 cell counts were performed 6-monthly over 18 months. The relationship between CD4 cell count and time on ART was investigated using regression analysis with fixed (population) and random (individual) effects, and age at ART initiation as a covariate.

Results

Of the 307 participants who initiated ART, the median age at initiation was 11.7 ye

SUBMITTER: Simms V 

PROVIDER: S-EPMC6125740 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature