Extensive host immune adaptation in a concentrated North American HIV epidemic.

ABSTRACT:

Objective

HIV incidence in the Canadian province of Saskatchewan, where Indigenous persons make up 80% of those infected, are among the highest on the continent. Reports of accelerated HIV progression, associated with carriage of certain human leukocyte antigen (HLA) alleles (including the typically protective HLA-B*51) have also emerged from the region. Given that acquisition of HIV preadapted to host HLA negatively impacts clinical outcome, we hypothesized that HIV-host adaptation may be elevated in Saskatchewan.

Design

Comparative analysis of population-level HIV sequence datasets from Saskatchewan and elsewhere in Canada/USA.

Methods

We analyzed 1144 HIV subtype B Pol sequences collected in Saskatchewan between 2000 and 2016, comprising ∼65% of cumulative provinci

SUBMITTER: Brumme ZL 

PROVIDER: S-EPMC6125742 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature