Transcription factor networks involved in cell death in the dorsal root ganglia following peripheral nerve injury.

ABSTRACT: The peripheral nervous system has the potential to regenerate after nerve injury owing to the intrinsic regrowth ability of neurons and the permissive microenvironment. The regenerative process involves numerous gene expression changes, in which transcription factors play a critical role. Previously, we profiled dysregulated genes in dorsal root ganglion neurons at different time points (0, 3 and 9 hours, and 1, 4 and 7 days) after sciatic nerve injury in rats by RNA sequencing. In the present study, we investigated differentially expressed transcription factors following nerve injury, and we identified enriched molecular and cellular functions of these transcription factors by Ingenuity Pathway Analysis. This analysis revealed the dynamic changes in the expression of transcription factors

SUBMITTER: Qin J 

PROVIDER: S-EPMC6126133 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature