Identification of RFC5 as a novel potential prognostic biomarker in lung cancer through bioinformatics analysis.

ABSTRACT: Lung cancer is the leading cause of mortalities among all types of cancer. Therefore, the screening of biomarkers that are related with the progression of lung cancer is crucial for early diagnosis and efficient therapy of lung cancer. In the present study, bioinformatic analysis identified replication factor C 5 (RFC5) as a potential novel oncogene in lung cancer. RFC5 functions as a clamp loader and is involved in DNA replication and repair. Analysis of public databases and reverse transcription-quantitative polymerase chain reaction indicated that RFC5 was significantly increased in tumor tissues compared with adjacent normal tissues. A high RFC5 expression was observed to be associated with more aggressive malignant clinicopathological features, including higher T stage, more advanced

SUBMITTER: Wang M 

PROVIDER: S-EPMC6126192 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature