Development and Validation of Nomograms for Predicting Overall and Breast Cancer-Specific Survival in Young Women with Breast Cancer: A Population-Based Study.

ABSTRACT:

Introduction

The objective of current study was to develop and validate comprehensive nomograms for predicting the survival of young women with breast cancer.

Methods

Women aged <40 years diagnosed with invasive breast cancer between 1990 and 2010 were selected from the Surveillance, Epidemiology, and End Results database and randomly divided into training (n = 12,465) and validation (n = 12,424) cohorts. A competing-risks model was used to estimate the probability of breast cancer-specific survival (BCSS). We identified and integrated significant prognostic factors for overall survival (OS) and BCSS to construct nomograms. The performance of the nomograms was assessed with respect to calibration, discrimination, and risk group stratification.

Results

The entire cohor

SUBMITTER: Gong Y 

PROVIDER: S-EPMC6126433 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature