Isolation of Retinal Arterioles for Ex Vivo Cell Physiology Studies.

ABSTRACT: The retina is a highly metabolically active tissue that requires a substantial blood supply. The retinal circulation supports the inner retina, while the choroidal vessels supply the photoreceptors. Alterations in retinal perfusion contribute to numerous sight-threatening disorders, including diabetic retinopathy, glaucoma and retinal branch vein occlusions. Understanding the molecular mechanisms involved in the control of blood flow through the retina and how these are altered during ocular disease could lead to the identification of new targets for the treatment of these conditions. Retinal arterioles are the main resistance vessels of the retina, and consequently, play a key role in regulating retinal hemodynamics through changes in luminal diameter. In recent years, we have developed m

SUBMITTER: Curtis TM 

PROVIDER: S-EPMC6126467 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature