ZNF259 promotes breast cancer cells invasion and migration via ERK/GSK3β/snail signaling.

ABSTRACT:

Purpose

Zinc finger protein 259 (ZNF259), also known as ZPR1, is a zinc finger-containing protein that can bind the intracellular tyrosine kinase domain of EGFR. At present, our knowledge on ZNF259 in cancers is limited. Here, we aimed to explore the biological functions of ZNF259 in breast cancer and reveal their mechanisms.

Patients and methods

The expression of ZNF259 was measured in 133 cases of breast cancer by immunohistochemistry. The online database Kaplan-Meier (KM) Plotter Online Tool was used to analyze the relationship between ZNF259 expression and breast cancer patient survival prognosis. Plasmid transfection and small interfering RNA and inhibitor treatments were carried out to explore the functions of ZNF259 in breast cancer cell lines and its potential mechan

SUBMITTER: Liu B 

PROVIDER: S-EPMC6126507 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature