Automated, Long-term Behavioral Assay for Cognitive Functions in Multiple Genetic Models of Alzheimer's Disease, Using IntelliCage.

ABSTRACT: Multiple factors-such as aging and genes-are frequently associated with cognitive decline. Genetically modified mouse models of cognitive decline, such as Alzheimer's disease (AD), have become a promising tool to elucidate the underlying mechanisms and promote the therapeutic advances. An important step is the validation and characterization of expected behavioral abnormality in the models, in the case of AD, cognitive decline. The long-term behavioral investigations of laboratory animals to study the effect of aging demand substantial efforts from researchers. The IntelliCage system is a high-throughput and cost-effective test battery for mice that eliminates the need for daily human handling. Here, we describe how the system is utilized in the long-term phenotyping of a genetic Alzheimer

SUBMITTER: Masuda A 

PROVIDER: S-EPMC6126617 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature