Intralesional treatment of metastatic melanoma: a review of therapeutic options.

ABSTRACT: Intralesional therapy of melanoma patients with locally advanced metastatic disease is attracting increasing interest, not least due to its ability to lead to both direct tumor cell killing and the stimulation of both a local and a systemic immune response. An obvious pre-requisite for this type of approach is the presence of accessible metastases that are amenable to direct injection with the therapeutic agent of interest. Patients who present with these characteristics belong to stages IIIB/C or IV of the disease. Surgical resection with intention to cure is the standard of care for patients with limited tumor burden and confined spread of disease (resectable patients). However, this category of patients is at a high risk of further recurrences until the disease becomes inoperable (unres

SUBMITTER: Weide B 

PROVIDER: S-EPMC6126622 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature