Modeling Rabbit Responses to Single and Multiple Aerosol Exposures of Bacillus anthracis Spores.

ABSTRACT: Survival models are developed to predict response and time-to-response for mortality in rabbits following exposures to single or multiple aerosol doses of Bacillus anthracis spores. Hazard function models were developed for a multiple-dose data set to predict the probability of death through specifying functions of dose response and the time between exposure and the time-to-death (TTD). Among the models developed, the best-fitting survival model (baseline model) is an exponential dose-response model with a Weibull TTD distribution. Alternative models assessed use different underlying dose-response functions and use the assumption that, in a multiple-dose scenario, earlier doses affect the hazard functions of each subsequent dose. In addition, published mechanistic models are analyzed and c

SUBMITTER: Coleman ME 

PROVIDER: S-EPMC6126673 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature