Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders.

ABSTRACT: While lizards and salamanders both exhibit the ability to regenerate amputated tails, the outcomes achieved by each are markedly different. Salamanders, such as Ambystoma mexicanum, regenerate nearly identical copies of original tails. Regenerated lizard tails, however, exhibit important morphological differences compared with originals. Some of these differences concern dorsoventral patterning of regenerated skeletal and spinal cord tissues; regenerated salamander tail tissues exhibit dorsoventral patterning, while regrown lizard tissues do not. Additionally, regenerated lizard tails lack characteristically roof plate-associated structures, such as dorsal root ganglia. We hypothesized that differences in neural stem cells (NSCs) found in the ependyma of regenerated spinal cords acc

SUBMITTER: Sun AX 

PROVIDER: S-EPMC6126763 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature