Linking systemic angiogenic markers to synovial vascularization in rheumatoid arthritis.

ABSTRACT:

Background

Neoangiogenesis is a crucial event to promote the development of the hyperplasic proliferative pathologic synovium in Rheumatoid arthritis (RA). Ultrasound (US) is sensitive for detection of power Doppler (PD) vascularization.

Objective

To explore the associations between a set of complementary circulating angiogenic markers and a comprehensive US assessment in patients with RA.

Patients and methods

Serum levels of eight angiogenic markers were measured by quantitative ELISAs in a total of 125 patients with RA, who were all systematically assessed in parallel by PDUS, performed on 32 joints.

Results

Serum levels of soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1) and Tie-2 were more likely to be increased in patients with synovial hyperemia detect

SUBMITTER: Leblond A 

PROVIDER: S-EPMC6126858 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature