Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus.

ABSTRACT: Protein production, genomic RNA replication, and virion assembly during infection by picornaviruses like human rhinovirus and poliovirus take place in the cytoplasm of infected human cells, making them the quintessential cytoplasmic pathogens. However, a growing body of evidence suggests that picornavirus replication is promoted by a number of host proteins localized normally within the host cell nucleus. To systematically identify such nuclear proteins, we focused on those that appear to re-equilibrate from the nucleus to the cytoplasm during infection of HeLa cells with human rhinovirus via quantitative protein mass spectrometry. Our analysis revealed a highly selective re-equilibration of proteins with known mRNA splicing and transport-related functions over nuclear proteins of all othe

SUBMITTER: Flather D 

PROVIDER: S-EPMC6126879 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature