Associations Between Change in Total and Free 25-Hydroxyvitamin D With 24,25-Dihydroxyvitamin D and Parathyroid Hormone.

ABSTRACT:

Context

The physiologic role of free 25-hydroxyvitamin D [25(OH)D] in humans is unclear.

Objective

To assess whether rise in total vs free 25(OH)D is associated with change in downstream biomarkers of 25(OH)D entry into target cells in kidney and parathyroid: 24,25-dihyroxyvitamin D [24,25(OH)2D] and PTH, respectively.

Design

16-week randomized controlled trial.

Intervention

60 μg (2400 IU)/d of D3 or 20 μg/d of 25(OH)D3.

Setting

Academic medical center.

Participants

35 adults age ≥18 years with 25(OH)D levels < 20 ng/mL.

Main outcome measures

24,25(OH)2D, 1,25-dihyroxyvitamin D [1,25(OH)2D] and PTH.

Results

At baseline, participants [D3 and 25(OH)D3 groups combined] were 35.1 ± 10.6 years. Mean total 25(OH)D, free 25(OH)D, 24,25(OH)

SUBMITTER: Shieh A 

PROVIDER: S-EPMC6126886 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature