Oxandrolone Treatment Results in an Increased Risk of Gonadarche in Prepubertal Boys With Klinefelter Syndrome.

ABSTRACT:

Context

Klinefelter syndrome (KS) is a common genetic condition in which males have an extra X chromosome. KS is associated with testosterone deficiency, neurodevelopmental delays, and cardiometabolic disorders. There has been recent interest in prepubertal androgen treatment; however, the effects on puberty and gonadal function are unknown.

Objective

To compare onset of puberty and testicular function in prepubertal boys treated with 2 years of oxandrolone (Ox) vs placebo (Pl).

Design

Double-blind, randomized, controlled trial.

Setting

Single tertiary care referral center.

Participants

Eighty prepubertal boys with KS; mean age: 8.0 ± 2.2 years (range: 4 to 12).

Interventions

Ox 0.05 mg/kg vs identical-appearing Pl capsule given for 2 years.

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SUBMITTER: Davis SM 

PROVIDER: S-EPMC6126887 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature