Subcutaneous Fat Fibrosis Links Obesity to Insulin Resistance in Chinese Americans.

ABSTRACT:

Objective

Type 2 diabetes presents at a lower body mass index (BMI) in Chinese individuals than in white individuals. We sought to determine the role of subcutaneous adipose tissue (SCAT)-intrinsic factors, vs BMI or adiposity per se, in the vulnerability of Chinese individuals to obesity-associated impairment of insulin sensitivity.

Research design and methods

Thirty-two Chinese and 30 white men and women from a cohort in the San Francisco Bay Area underwent anthropometric measurements, body composition (dual-energy X-ray absorptiometry) analyses, and measurement of fasting plasma glucose and insulin. Forty-eight also provided abdominal SCAT samples for transcriptional and biochemical analyses of tissue fibrosis.

Results

BMI correlated with total body fat in white (r

SUBMITTER: Alba DL 

PROVIDER: S-EPMC6126891 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature