Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies.

ABSTRACT:

Background

Sex hormones in serum have been hypothesized to influence the risk of prostate cancer. We performed a collaborative analysis of the existing worldwide epidemiologic data to examine these associations in a uniform manner and to provide more precise estimates of risks.

Methods

Data on serum concentrations of sex hormones from 18 prospective studies that included 3886 men with incident prostate cancer and 6438 control subjects were pooled by the Endogenous Hormones and Prostate Cancer Collaborative Group. Relative risks (RRs) of prostate cancer by fifths of serum hormone concentration were estimated by use of conditional logistic regression with stratification by study, age at recruitment, and year of recruitment. All statistical tests were two-sided.

Results

SUBMITTER: Endogenous Hormones and Prostate Cancer Collaborative Group 

PROVIDER: S-EPMC6126902 | biostudies-literature | 2008 Feb

REPOSITORIES: biostudies-literature