An exclusive metabolic niche enables strain engraftment in the gut microbiota.

ABSTRACT: The dense microbial ecosystem in the gut is intimately connected to numerous facets of human biology, and manipulation of the gut microbiota has broad implications for human health. In the absence of profound perturbation, the bacterial strains that reside within an individual are mostly stable over time ¹ . By contrast, the fate of exogenous commensal and probiotic strains applied to an established microbiota is variable, generally unpredictable and greatly influenced by the background microbiota^2,3. Therefore, analysis of the factors that govern strain engraftment and abundance is of critical importance to the emerging field of microbiome reprogramming. Here we generate an exclusive metabolic niche in mice via administration of a marine polysaccharide, porphyran, an

SUBMITTER: Shepherd ES 

PROVIDER: S-EPMC6126907 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature