Regulation of contact sensitivity in non-obese diabetic (NOD) mice by innate immunity.

ABSTRACT:

Background

Genetic background influences allergic immune responses to environmental stimuli. Non-obese diabetic (NOD) mice are highly susceptible to environmental stimuli. Little is known about the interaction of autoimmune genetic factors with innate immunity in allergies, especially skin hypersensitivity.

Objectives

To study the interplay of innate immunity and autoimmune genetic factors in contact hypersensitivity (CHS) by using various innate immunity-deficient NOD mice.

Methods

Toll-like receptor (TLR) 2-deficient, TLR9-deficient and MyD88-deficient NOD mice were used to investigate CHS. The cellular mechanism was determined by flow cytometry in vitro and adoptive cell transfer in vivo. To investigate the role of MyD88 in dendritic cells (DCs) in CHS, we also use

SUBMITTER: Szczepanik M 

PROVIDER: S-EPMC6126938 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature