Knob protein enhances epithelial barrier integrity and attenuates airway inflammation.

ABSTRACT:

Background

Altered epithelial physical and functional barrier properties along with T_H1/T_H2 immune dysregulation are features of allergic asthma. Regulation of junction proteins to improve barrier function of airway epithelial cells has the potential for alleviation of allergic airway inflammation.

Objective

We sought to determine the immunomodulatory effect of knob protein of the adenoviral capsid on allergic asthma and to investigate its mechanism of action on airway epithelial junction proteins and barrier function.

Methods

Airway inflammation, including junction protein expression, was evaluated in allergen-challenged mice with and without treatment with knob. Human bronchial epithelial cells were exposed to knob, and its effects on expressio

SUBMITTER: Ha SG 

PROVIDER: S-EPMC6126992 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature