Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium.

ABSTRACT: The intestinal epithelium is a single layer of cells which provides the first line of defence of the intestinal mucosa to bacterial infection. Cohesion of this physical barrier is supported by renewal of epithelial stem cells, residing in invaginations called crypts, and by crypt cell migration onto protrusions called villi; dysregulation of such mechanisms may render the gut susceptible to chronic inflammation. The impact that excessive or misplaced epithelial cell death may have on villus cell migration is currently unknown. We integrated cell-tracking methods with computational models to determine how epithelial homeostasis is affected by acute and chronic TNFα-driven epithelial cell death. Parameter inference reveals that acute inflammatory cell death has a transient effect on epitheli

SUBMITTER: Muraro D 

PROVIDER: S-EPMC6127161 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature