PD-1 Expression on <i>Mycobacterium tuberculosis</i>-Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis.

ABSTRACT: Persistent antigen stimulation in chronic infections has been associated with antigen-specific T cell dysfunction and upregulation of inhibitory receptors, including programmed cell death protein 1 (PD-1). Pulmonary tuberculosis (TB) disease is characterized by high levels of Mycobacterium tuberculosis (Mtb), yet the relationship between bacterial load, PD-1 expression, and Mtb-specific T cell function in human TB has not been well-defined. Using peripheral blood samples from adults with LTBI and with pulmonary TB disease, we tested the hypothesis that PD-1 expression is associated with bacterial load and functional capacity of Mtb-specific T cell responses. We found that PD-1 was expressed at significantly higher levels on Th1 cytokine-producing Mtb-specific CD4 T cells from patien

SUBMITTER: Day CL 

PROVIDER: S-EPMC6127207 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature