Physiological and Pathophysiological Relevance of the Anion Transporter Slc26a9 in Multiple Organs.

ABSTRACT: Transepithelial Cl^- and HCO₃^- transport is crucial for the function of all epithelia, and HCO₃^- is a biological buffer that maintains acid-base homeostasis. In most epithelia, a series of Cl^-/HCO₃^- exchangers and Cl^- channels that mediate Cl^- absorption and HCO₃^- secretion have been detected in the luminal and basolateral membranes. Slc26a9 belongs to the solute carrier 26 (Slc26) family of anion transporters expressed in the epithelia of multiple organs. This review summarizes the expression pattern and functional diversity of Slc26a9 in different systems based on all investigations performed thus far. Furthermore, the physical and functional interactions bet

SUBMITTER: Liu X 

PROVIDER: S-EPMC6127633 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature