Reactive Laser Ablation Electrospray Ionization Time-Resolved Mass Spectrometry of Click Reactions.

ABSTRACT: Reactions in confined compartments like charged microdroplets are of increasing interest, notably because of their substantially increased reaction rates. When combined with ambient ionization mass spectrometry (MS), reactions in charged microdroplets can be used to improve the detection of analytes or to study the molecular details of the reactions in real time. Here, we introduce a reactive laser ablation electrospray ionization (reactive LAESI) time-resolved mass spectrometry (TRMS) method to perform and study reactions in charged microdroplets. We demonstrate this approach with a class of reactions new to reactive ambient ionization MS: so-called click chemistry reactions. Click reactions are high-yielding reactions with a high atom efficiency, and are currently drawing significant att

SUBMITTER: van Geenen FAMG 

PROVIDER: S-EPMC6127799 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature