SH2B1 promotes NSCLC cell proliferation through PI3K/Akt/mTOR signaling cascade.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC), the most prevalent type of human lung cancer, is characterized by many molecular abnormalities. SH2B1, a member of the SH2-domain containing family, have recently been shown to act as tumor activators in multiple cancers. The objective of this study was to investigate the role SH2B1 and the underlying molecular mechanism in NSCLC.

Methods

Cell functional analysis and cell line-derived xenograft model were performed to determine SH2B1 potential roles on NSCLC cell proliferation in vitro and in vivo. In vitro assays were performed to identify signal molecular mechanisms. Subsequently, 104 patients with NSCLC undergoing primary surgical resection were recruited to evaluated expression of SH2B1 and Akt/mTOR signaling markers by immu

SUBMITTER: Wang S 

PROVIDER: S-EPMC6127928 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature