Dosimetric analysis and comparison of reduced longitudinal cranial margins of VMAT-IMRT of rectal cancer.

ABSTRACT:

Background

The cranial border of the target volume (TV) in rectal cancer patients treated with neoadjuvant chemoradiation (nCRT) is mostly defined at the level of L5/S1. However, current studies have shown that relapse cranially of the target volume after neoadjuvant nCRT and surgery is very rare. A reduction of cranial TV margins could be reasonable to reduce toxicity to the organs at risk (OAR). In this study we compared the dose distribution to the OAR for different cranial longitudinal margins using a dose-volume histogram (DVH) analysis.

Methods

Ten patients with loco regional advanced rectal cancer were analysed retrospectively. All patients were planned for Volumetric Arc Therapy Radiation Therapy (VMAT). Next to the original PTV (PTV0), three new planning target volu

SUBMITTER: Dapper H 

PROVIDER: S-EPMC6127934 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature