The combination of induced pluripotent stem cells and bioscaffolds holds promise for spinal cord regeneration.

ABSTRACT: Spinal cord injuries (SCIs) are debilitating conditions for which no effective treatment currently exists. The damage of neural tissue causes disruption of neural tracts and neuron loss in the spinal cord. Stem cell replacement offers a solution for SCI treatment by providing a source of therapeutic cells for neural function restoration. Induced pluripotent stem cells (iPSCs) have been investigated as a potential type of stem cell for such therapies. Transplantation of iPSCs has been shown to be effective in restoring function after SCIs in animal models while they circumvent ethical and immunological concerns produced by other stem cell types. Another approach for the treatment of SCI involves the graft of a bioscaffold at the site of injury to create a microenvironment that enhances cell

SUBMITTER: DeBrot A 

PROVIDER: S-EPMC6128052 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature