Combined VEGF/PDGF improves olfactory regeneration after unilateral bulbectomy in mice.

ABSTRACT: The olfactory receptor neurons lining the nasal cavity have a remarkable capacity to regenerate throughout life. They are replenished continuously and their axons make new connections within the olfactory bulb. However, some factors such as head trauma and skull base surgery damage the olfactory nerve which lead to olfactory dysfunction. Losing the sense of smell has considerable effects on quality of life and life-expectancy. Therefore, there is a clear need to find a treatment for olfactory dysfunction. One such potential treatment is growth factor therapy which showed promising results in the spinal cord and brain injuries. The aim of the present study was to investigate whether combined delivery of two growth factors, vascular endothelial growth factor and platelet-derived growth facto

SUBMITTER: Beecher K 

PROVIDER: S-EPMC6128065 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature