Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale.

ABSTRACT: The triterpenes are one of the largest and most structurally diverse families of plant natural products. Many triterpene derivatives have been shown to possess medicinally relevant biological activity. However, thus far this potential has not translated into a plethora of triterpene-derived drugs in the clinic. This is arguably (at least partially) a consequence of limited practical synthetic access to this class of compound, a problem that can stifle the exploration of structure-activity relationships and development of lead candidates by traditional medicinal chemistry workflows. Despite their immense diversity, triterpenes are all derived from a single linear precursor, 2,3-oxidosqualene. Transient heterologous expression of biosynthetic enzymes in N. benthamiana can divert endogenous s

SUBMITTER: Stephenson MJ 

PROVIDER: S-EPMC6128107 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature