Association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis: A systematic review and meta-analysis.

ABSTRACT:

Objective

To assess the association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis (OA), a systematic review and meta-analysis was conducted.

Methods

A total of 17 relevant case-control studies with 7424 cases and 11,310 controls was collected from several electronic databases up to June 2018.

Results

The pooled results showed that GDF-5 rs143383 polymorphism was significantly associated with radiographic defined knee OA in overall and stratified analysis by ethnicity, source of controls and genotyping techniques.

Conclusions

The GDF-5 rs143383 polymorphism might be used as a relevant risk estimate for radiographic defined Knee OA.

SUBMITTER: Aghili K 

PROVIDER: S-EPMC6128174 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature